解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The central complex is a highly conserved insect brain region composed of morphologically stereotyped neurons that arborize in distinctively shaped substructures. The region is implicated in a wide range of behaviors and several modeling studies have explored its circuit computations. Most studies have relied on assum...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37017
更新日期:2018-08-20 00:00:00
abstract::Cognitive control proactively configures information processing to suit expected task demands. Predictions of forthcoming demand can be driven by explicit external cues or be generated internally, based on past experience (cognitive history). However, it is not known whether and how the brain reconciles these two sour...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.39497
更新日期:2018-08-16 00:00:00
abstract::K146N is a dominant mutation in human β-cardiac myosin heavy chain, which causes hypertrophic cardiomyopathy. We examined how Drosophila muscle responds to this mutation and integratively analyzed the biochemical, physiological and mechanical foundations of the disease. ATPase assays, actin motility, and indirect flig...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.38064
更新日期:2018-08-13 00:00:00
abstract::Analysis of the spatial distribution of endomembrane trafficking is fundamental to understand the mechanisms controlling cellular dynamics, cell homeostasy, and cell interaction with its external environment in normal and pathological situations. We present a semi-parametric framework to quantitatively analyze and vis...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32311
更新日期:2018-08-09 00:00:00
abstract:: ...
journal_title:eLife
pub_type: 杂志文章,已发布勘误
doi:10.7554/eLife.40515
更新日期:2018-08-02 00:00:00
abstract::During development, neurons form synapses with their fate-determined targets. While we begin to elucidate the mechanisms by which extracellular ligand-receptor interactions enhance synapse specificity by inhibiting synaptogenesis, our knowledge about their intracellular mechanisms remains limited. Here we show that Ra...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.38801
更新日期:2018-07-31 00:00:00
abstract::The orbitofrontal cortex (OFC) is critical for updating reward-directed behaviours flexibly when outcomes are devalued or when task contingencies are reversed. Failure to update behaviour in outcome devaluation and reversal learning procedures are considered canonical deficits following OFC lesions in non-human primat...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37357
更新日期:2018-07-25 00:00:00
abstract::Yes. ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.40018
更新日期:2018-07-23 00:00:00
abstract::Mature microRNAs (miRNAs) are processed from primary transcripts (pri-miRNAs), and their expression is controlled at transcriptional and post-transcriptional levels. However, how regulation at multiple levels achieves precise control remains elusive. Using published and new datasets, we profile a time course of mature...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.38389
更新日期:2018-07-19 00:00:00
abstract::In vivo, the primary molecular mechanotransductive events mechanically initiating cell differentiation remain unknown. Here we find the molecular stretching of the highly conserved Y654-β-catenin-D665-E-cadherin binding site as mechanically induced by tissue strain. It triggers the increase of accessibility of the Y65...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33381
更新日期:2018-07-19 00:00:00
abstract::Heritable variation in gene expression forms a crucial bridge between genomic variation and the biology of many traits. However, most expression quantitative trait loci (eQTLs) remain unidentified. We mapped eQTLs by transcriptome sequencing in 1012 yeast segregants. The resulting eQTLs accounted for over 70% of the h...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35471
更新日期:2018-07-17 00:00:00
abstract::The HIF (hypoxia-inducible factor) transcription factor is the master regulator of the metazoan response to chronic hypoxia. In addition to promoting adaptations to low oxygen, HIF drives cytoprotective mechanisms in response to stresses and modulates neural circuit function. How most HIF targets act in the control of...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36828
更新日期:2018-07-16 00:00:00
abstract::Metazoan development depends on tightly regulated gene expression programs that instruct progenitor cells to adopt specialized fates. Recent work found that posttranslational modifications, such as monoubiquitylation, can determine cell fate also independently of effects on transcription, yet how monoubiquitylation is...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35407
更新日期:2018-07-12 00:00:00
abstract::Recent lineage tracing analyses have significantly improved our understanding of immune system development and highlighted the importance of the different hematopoietic waves. The current challenge is to understand whether these waves interact and whether this affects the function of the immune system. Here we report ...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34890
更新日期:2018-07-11 00:00:00
abstract::Behavior relies on the ability of sensory systems to infer properties of the environment from incoming stimuli. The accuracy of inference depends on the fidelity with which behaviorally relevant properties of stimuli are encoded in neural responses. High-fidelity encodings can be metabolically costly, but low-fidelity...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32055
更新日期:2018-07-10 00:00:00
abstract::The neural control of transition between posture and movement encompasses the regulation of reflex-stabilizing mechanisms to enable motion. Optimal feedback theory suggests that such transitions require the disengagement of one motor control policy before the implementation of another. To test this possibility, we inv...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36123
更新日期:2018-07-10 00:00:00
abstract::Optogenetic approaches are leading to a better understanding of the forces that determine the plane of cell division. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.38748
更新日期:2018-07-09 00:00:00
abstract::Exhaustion of stem cells is a hallmark of aging. In the Drosophila testis, dedifferentiated germline stem cells (GSCs) derived from spermatogonia increase during lifespan, leading to the model that dedifferentiation counteracts the decline of GSCs in aged males. To test this, we blocked dedifferentiation by mis-expres...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36095
更新日期:2018-07-09 00:00:00
abstract::The emergence of subpopulations that perform distinct metabolic roles has been observed in populations of genetically identical bacteria. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.38578
更新日期:2018-06-29 00:00:00
abstract::A major challenge in neuroscience is to longitudinally monitor whole brain activity across multiple spatial scales in the same animal. Functional UltraSound (fUS) is an emerging technology that offers images of cerebral blood volume over large brain portions. Here we show for the first time its capability to resolve t...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35028
更新日期:2018-06-28 00:00:00
abstract::Glucocorticoid receptor (GR) is crucial for signaling mediated by stress-induced high levels of glucocorticoids. The lateral nucleus of the amygdala (LA) is a key structure underlying auditory-cued fear conditioning. Here, we demonstrate that genetic disruption of GR in the LA (LAGRKO) resulted in an auditory-cued fea...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34135
更新日期:2018-06-26 00:00:00
abstract::In most animals, the brain controls the body via a set of descending neurons (DNs) that traverse the neck. DN activity activates, maintains or modulates locomotion and other behaviors. Individual DNs have been well-studied in species from insects to primates, but little is known about overall connectivity patterns acr...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34272
更新日期:2018-06-26 00:00:00
abstract::Maintenance of transcription programs is challenged during mitosis when chromatin becomes condensed and transcription is silenced. How do the daughter cells re-establish the original transcription program? Here, we report that the TATA-binding protein (TBP), a key component of the core transcriptional machinery, remai...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35621
更新日期:2018-06-25 00:00:00
abstract::How proteins harness mechanical force to control function is a significant biological question. Here we describe a human cell surface receptor that couples ligand binding and force to trigger a chemical event which controls the adhesive properties of the receptor. Our studies of the secreted platelet oxidoreductase, E...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34843
更新日期:2018-06-22 00:00:00
abstract::Shade avoidance syndrome enables shaded plants to grow and compete effectively against their neighbors. In Arabidopsis, the shade-induced de-phosphorylation of the transcription factor PIF7 (PHYTOCHROME-INTERACTING FACTOR 7) is the key event linking light perception to stem elongation. However, the mechanism through w...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.31636
更新日期:2018-06-21 00:00:00
abstract::Most cellular features have a range of states, but understanding the mechanisms responsible for interspecific divergence is a challenge for evolutionary cell biology. Models are developed for the distribution of mean phenotypes likely to evolve under the joint forces of mutation and genetic drift in the face of consta...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34820
更新日期:2018-06-21 00:00:00
abstract::Regulation of protein turnover allows cells to react to their environment and maintain homeostasis. Proteins can show different turnover rates in different tissue, but little is known about protein turnover in different brain cell types. We used dynamic SILAC to determine half-lives of over 5100 proteins in rat primar...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34202
更新日期:2018-06-19 00:00:00
abstract::Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes. Accordingly, T cells exhibited low basal glycolytic flux and limite...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.30938
更新日期:2018-06-18 00:00:00
abstract::Although activation/deactivation of specific brain regions has been shown to be predictive of successful memory encoding, the relationship between time-varying large-scale brain networks and fluctuations of memory encoding performance remains unclear. Here, we investigated time-varying functional connectivity patterns...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.32696
更新日期:2018-06-18 00:00:00
abstract::Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches. The mechanisms that generate these distinct patterns of progeny are poorly understood. U...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.36739
更新日期:2018-06-13 00:00:00
abstract::Alzheimer's and Parkinson's disease are late onset neurodegenerative diseases that will require therapy over decades to mitigate the effects of disease-driving proteins such tau and α-synuclein (α-Syn). Previously we found that TRIM28 regulates the levels and toxicity of α-Syn and tau (
pub_type: 杂志文章
doi:10.7554/eLife.36768
更新日期:2018-06-04 00:00:00
abstract::The training of PhD students and early-career scientists is largely an apprenticeship in which the trainee associates with an expert to become an independent scientist. But when is a PhD student ready to graduate, a postdoctoral scholar ready for an independent position, or an early-career scientist ready for advanced...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34801
更新日期:2018-05-31 00:00:00
abstract::Transport of biologically active molecules across tight epithelial barriers is a major challenge preventing therapeutic peptides from oral drug delivery. Here, we identify a set of synthetic glycosphingolipids that harness the endogenous process of intracellular lipid-sorting to enable mucosal absorption of the incret...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34469
更新日期:2018-05-31 00:00:00
abstract::Muscles organise pseudo-crystalline arrays of actin, myosin and titin filaments to build force-producing sarcomeres. To study sarcomerogenesis, we have generated a transcriptomics resource of developing Drosophila flight muscles and identified 40 distinct expression profile clusters. Strikingly, most sarcomeric compon...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34058
更新日期:2018-05-30 00:00:00
abstract::Visual perception and imagery rely on similar representations in the visual cortex. During perception, visual activity is characterized by distinct processing stages, but the temporal dynamics underlying imagery remain unclear. Here, we investigated the dynamics of visual imagery in human participants using magnetoenc...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.33904
更新日期:2018-05-29 00:00:00
abstract::Vitamin B12 (cobalamin) is the most complex B-type vitamin and is synthetized exclusively in a limited number of prokaryotes. Its biologically active variants contain rare organometallic bonds, which are used by enzymes in a variety of central metabolic pathways such as L-methionine synthesis and ribonucleotide reduct...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.35828
更新日期:2018-05-29 00:00:00
abstract::CpG islands are gene regulatory elements associated with the majority of mammalian promoters, yet how they regulate gene expression remains poorly understood. Here, we identify FBXL19 as a CpG island-binding protein in mouse embryonic stem (ES) cells and show that it associates with the CDK-Mediator complex. We discov...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.37084
更新日期:2018-05-29 00:00:00
abstract::The IFNλ family of interferons controls the spread of viruses in the upper respiratory tract and transmission between mice. ...
journal_title:eLife
pub_type: 评论,杂志文章
doi:10.7554/eLife.37552
更新日期:2018-05-24 00:00:00
abstract::How producers of public goods persist in microbial communities is a major question in evolutionary biology. Cooperation is evolutionarily unstable, since cheating strains can reproduce quicker and take over. Spatial structure has been shown to be a robust mechanism for the evolution of cooperation. Here we study how s...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34862
更新日期:2018-05-22 00:00:00
abstract::The vascular pathogen Verticillium dahliae infects the roots of plants to cause Verticillium wilt. The molecular mechanisms underlying V. dahliae virulence and host resistance remain elusive. Here, we demonstrate that a secretory protein, VdSCP41, functions as an intracellular effector that promotes V. dahliae virulen...
journal_title:eLife
pub_type: 杂志文章
doi:10.7554/eLife.34902
更新日期:2018-05-14 00:00:00